Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting

The human Ether-à-go-go related gene (hERG) potassium channel is responsible for the rapid delayed rectifier potassium current that plays a critical role in the repolarization of cardiomyocytes during the cardiac action potential. In humans, inhibition of hERG by drugs can prolong the electrocardiog...

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Detalhes bibliográficos
Main Authors: Huang, Xi-Ping, Mangano, Thomas, Hufeisen, Sandy, Setola, Vincent, Roth, Bryan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Ion Channels and Transporters Focus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002179/
https://ncbi.nlm.nih.gov/pubmed/21158687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2010.0331
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