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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

Mutations in DJ-1, PINK1 (PTEN-induced putative kinase 1) and parkin all cause recessive parkinsonism in humans, but the relationships between these genes are not clearly defined. One event associated with loss of any of these genes is altered mitochondrial function. Recent evidence suggests that tu...

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Autores principales: Thomas, Kelly Jean, McCoy, Melissa K., Blackinton, Jeff, Beilina, Alexandra, van der Brug, Marcel, Sandebring, Anna, Miller, David, Maric, Dragan, Cedazo-Minguez, Angel, Cookson, Mark R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000675/
https://ncbi.nlm.nih.gov/pubmed/20940149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq430
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