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Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways
Three genes have been identified that cause, in humans, autosomally inherited parkinsonism. These are PARK2, encoding the E3 ubiquitin ligase parkin; PINK1, a mitochondrial kinase; and PARK7, which codes for the protein DJ-1. In several experimental systems, it has been shown that all three proteins...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426824/ https://ncbi.nlm.nih.gov/pubmed/22951446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a009415 |
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