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Conformational Rearrangements to the Intracellular Open States of the LeuT and ApcT Transporters Are Modulated by Common Mechanisms

Recent crystallographic studies revealed that five transporter families without much sequence similarities among them have similar structure folds to LeuT, a bacterial neurotransmitter:sodium symporter homolog. The LeuT fold is characterized by an internal twofold structural pseudosymmetry. The tran...

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Autori principali: Shi, Lei, Weinstein, Harel
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000488/
https://ncbi.nlm.nih.gov/pubmed/21156121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.10.003
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