Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

BACKGROUND: Current evidence suggests a role of neuroinflammation in the pathogenesis of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of basal ganglia injury. Reportedly, nonsteroidal anti-inflammatory drugs (NSAIDs) mitigate DAergic neurotoxicit...

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Autors principals: L'Episcopo, Francesca, Tirolo, Cataldo, Caniglia, Salvatore, Testa, Nunzio, Serra, Pier A, Impagnatiello, Francesco, Morale, Maria C, Marchetti, Bianca
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000390/
https://ncbi.nlm.nih.gov/pubmed/21092260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-83
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