Wnt/B-Catenin Signaling is Required to Rescue Midbrain Dopaminergic Progenitors and Promote Neurorepair in Ageing Mouse Model of Parkinson’s Disease

Wnt/β-catenin signaling is required for specification and neurogenesis of midbrain dopaminergic (mDA) neurons, the pivotal neuronal population that degenerates in Parkinson’s disease (PD) and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. Wnt/β-catenin signaling plays a vi...

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Hauptverfasser: L’Episcopo, Francesca, Tirolo, Cataldo, Testa, Nunzio, Caniglia, Salvatore, Morale, Maria Concetta, Serapide, Maria Francesca, Pluchino, Stefano, Marchetti, Bianca
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106883/
https://ncbi.nlm.nih.gov/pubmed/24648001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1708
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