Aging-Induced Nrf2-ARE Pathway Disruption in the Subventricular Zone Drives Neurogenic Impairment in Parkinsonian Mice via PI3K-Wnt/β-Catenin Dysregulation

Aging and exposure to environmental toxins including MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) are strong risk factors for developing Parkinson's disease (PD), a common neurologic disorder characterized by selective degeneration of midbrain dopaminergic (DAergic) neurons and astroglio...

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Detalhes bibliográficos
Main Authors: L'Episcopo, Francesca, Tirolo, Cataldo, Testa, Nunzio, Caniglia, Salvatore, Morale, Maria C., Impagnatiello, Francesco, Pluchino, Stefano, Marchetti, Bianca
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564519/
https://ncbi.nlm.nih.gov/pubmed/23345222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3206-12.2013
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