Deletion of CDKAL1 Affects Mitochondrial ATP Generation and First-Phase Insulin Exocytosis

BACKGROUND: A variant of the CDKAL1 gene was reported to be associated with type 2 diabetes and reduced insulin release in humans; however, the role of CDKAL1 in β cells is largely unknown. Therefore, to determine the role of CDKAL1 in insulin release from β cells, we studied insulin release profile...

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Hauptverfasser: Ohara-Imaizumi, Mica, Yoshida, Masashi, Aoyagi, Kyota, Saito, Taro, Okamura, Tadashi, Takenaka, Hitoshi, Akimoto, Yoshihiro, Nakamichi, Yoko, Takanashi-Yanobu, Rieko, Nishiwaki, Chiyono, Kawakami, Hayato, Kato, Norihiro, Hisanaga, Shin-ichi, Kakei, Masafumi, Nagamatsu, Shinya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000340/
https://ncbi.nlm.nih.gov/pubmed/21151568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015553
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