Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis

The mechanism of glucose-induced biphasic insulin release is unknown. We used total internal reflection fluorescence (TIRF) imaging analysis to reveal the process of first- and second-phase insulin exocytosis in pancreatic β cells. This analysis showed that previously docked insulin granules fused a...

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Detalhes bibliográficos
Main Authors: Ohara-Imaizumi, Mica, Fujiwara, Tomonori, Nakamichi, Yoko, Okamura, Tadashi, Akimoto, Yoshihiro, Kawai, Junko, Matsushima, Satsuki, Kawakami, Hayato, Watanabe, Takashi, Akagawa, Kimio, Nagamatsu, Shinya
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064214/
https://ncbi.nlm.nih.gov/pubmed/17502420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200608132
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