Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic β-Cells

In glucose-induced insulin secretion from pancreatic β-cells, a population of insulin granules fuses with the plasma membrane without the typical docking process (newcomer granule fusions), however, its mechanism is unclear. In this study, we investigated the PI3K signaling pathways involved in the...

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Bibliographische Detailangaben
Hauptverfasser: Aoyagi, Kyota, Ohara-Imaizumi, Mica, Nishiwaki, Chiyono, Nakamichi, Yoko, Ueki, Kohjiro, Kadowaki, Takashi, Nagamatsu, Shinya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471824/
https://ncbi.nlm.nih.gov/pubmed/23077605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047381
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