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Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic β-Cells

In glucose-induced insulin secretion from pancreatic β-cells, a population of insulin granules fuses with the plasma membrane without the typical docking process (newcomer granule fusions), however, its mechanism is unclear. In this study, we investigated the PI3K signaling pathways involved in the...

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書誌詳細
主要な著者: Aoyagi, Kyota, Ohara-Imaizumi, Mica, Nishiwaki, Chiyono, Nakamichi, Yoko, Ueki, Kohjiro, Kadowaki, Takashi, Nagamatsu, Shinya
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471824/
https://ncbi.nlm.nih.gov/pubmed/23077605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047381
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