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Interleukin 4 inhibits TGF-β-induced-Foxp3(+)T cells and generates, in combination with TGF-β, Foxp3(−) effector T cells that produce interleukins 9 and 10
Foxp3 is a key transcription factor involved in the generation and function of regulatory T (T(reg)) cells. Transforming growth factor β (TGF-β) induces Foxp3, which generates inducible Foxp3(+) T(reg) cells from naïve T cells, and interleukin 6 (IL-6) inhibits the generation of inducible T(reg) cel...
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| Auteurs principaux: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2999006/ https://ncbi.nlm.nih.gov/pubmed/18997793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1677 |
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