IL-9 induces differentiation of T(H)17 cells and enhances function of FoxP3(+) natural regulatory T cells

The development of T helper (T(H))17 and regulatory T (T(reg)) cells is reciprocally regulated by cytokines. Transforming growth factor (TGF)-β alone induces FoxP3(+) T(reg) cells, but together with IL-6 or IL-21 induces T(H)17 cells. Here we demonstrate that IL-9 is a key molecule that affects diff...

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Détails bibliographiques
Auteurs principaux: Elyaman, Wassim, Bradshaw, Elizabeth M., Uyttenhove, Catherine, Dardalhon, Valérie, Awasthi, Amit, Imitola, Jaime, Bettelli, Estelle, Oukka, Mohamed, van Snick, Jacques, Renauld, Jean-Christophe, Kuchroo, Vijay K., Khoury, Samia J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722314/
https://ncbi.nlm.nih.gov/pubmed/19433802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812530106
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