IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3(+) regulatory T cells

The conditions leading to the induction of adaptive Foxp3(+) regulatory T cells (T-regs) from peripheral T cells in vivo are incompletely understood. Here, we show that unresponsiveness of T cells to IL-6 by T cell-selective deletion of gp130 or immunization of wild-type mice with antigen in incompl...

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Detalhes bibliográficos
Main Authors: Korn, Thomas, Mitsdoerffer, Meike, Croxford, Andrew L., Awasthi, Amit, Dardalhon, Valérie A., Galileos, George, Vollmar, Patrick, Stritesky, Gretta L., Kaplan, Mark H., Waisman, Ari, Kuchroo, Vijay K., Oukka, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587589/
https://ncbi.nlm.nih.gov/pubmed/19015529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809850105
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