Interleukin 4 inhibits TGF-β-induced-Foxp3(+)T cells and generates, in combination with TGF-β, Foxp3(−) effector T cells that produce interleukins 9 and 10

Foxp3 is a key transcription factor involved in the generation and function of regulatory T (T(reg)) cells. Transforming growth factor β (TGF-β) induces Foxp3, which generates inducible Foxp3(+) T(reg) cells from naïve T cells, and interleukin 6 (IL-6) inhibits the generation of inducible T(reg) cel...

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Hauptverfasser: Dardalhon, Valérie, Awasthi, Amit, Kwon, Hyoung, Galileos, George, Gao, Wenda, Sobel, Raymond A., Mitsdoerffer, Meike, Strom, Terry B., Elyaman, Wassim, Ho, I-Cheng, Khoury, Samia, Oukka, Mohamed, Kuchroo, Vijay K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999006/
https://ncbi.nlm.nih.gov/pubmed/18997793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1677
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