Resistance Profiles of Novel Electrostatically Constrained HIV-1 Fusion Inhibitors

Human immunodeficiency virus (HIV) gp41 plays a key role in viral fusion; the N- and C-terminal heptad repeats (N-HR and C-HR) of gp41 form a stable 6-helical conformation for fusion. Therefore, HR-derived peptides, such as enfuvirtide (T-20), inhibit HIV-1 fusion by acting as decoys, and have been...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shimura, Kazuya, Nameki, Daisuke, Kajiwara, Keiko, Watanabe, Kentaro, Sakagami, Yasuko, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao, Sarafianos, Stefan G., Kodama, Eiichi N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Microbiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998136/
https://ncbi.nlm.nih.gov/pubmed/20937812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145789
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