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High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence

Historically, the safety of live attenuated vaccine candidates against neurotropic viruses was assessed by semi-quantitative analysis of virus-induced histopathology in the central nervous system of monkeys. We have developed a high-throughput automated image analysis (AIA) for the quantitative asse...

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Main Authors: Maximova, Olga A., Murphy, Brian R., Pletnev, Alexander G.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997939/
https://ncbi.nlm.nih.gov/pubmed/20688036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.07.070
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