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The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3′ non-coding region of the genome

Tick-borne encephalitis (TBE) is a severe disease affecting thousands of people throughout Eurasia. Despite the use of formalin-inactivated vaccines in endemic areas, an increasing incidence of TBE emphasizes the need for an alternative vaccine that will induce a more durable immunity against TBE vi...

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Detalhes bibliográficos
Main Authors: Engel, Amber R., Rumyantsev, Alexander A., Maximova, Olga A., Speicher, James M., Heiss, Brian, Murphy, Brian R., Pletnev, Alexander G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914112/
https://ncbi.nlm.nih.gov/pubmed/20594569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.06.014
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