Chimeric Tick-Borne Encephalitis/Dengue Virus Is Attenuated in Ixodes scapularis Ticks and Aedes aegypti Mosquitoes

In an effort to derive an efficacious live attenuated vaccine against tick-borne encephalitis, we generated a chimeric virus bearing the structural protein genes of a Far Eastern subtype of tick-borne encephalitis virus (TBEV) on the genetic background of recombinant dengue 4 (DEN4) virus. Introduct...

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Main Authors: Engel, Amber R., Mitzel, Dana N., Hanson, Christopher T., Wolfinbarger, James B., Bloom, Marshall E., Pletnev, Alexander G.
格式: Artigo
語言:Inglês
出版: Mary Ann Liebert, Inc. 2011
主題:
Viruses
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115420/
https://ncbi.nlm.nih.gov/pubmed/21142950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vbz.2010.0179
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