Cyclopeptide Smac mimetics as antagonists of IAP proteins

Two cyclopeptidic Smac mimetics, 2 and 3, were designed and synthesized. These two compounds bind to XIAP and cIAP-1/2 with low nanomolar affinities, and restore the activities of caspase-9 and caspase-3/-7 inhibited by XIAP. Compound 2 potently inhibits cancer cell growth and is 5–8 times more pote...

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Hauptverfasser: Sun, Haiying, Liu, Liu, Lu, Jianfeng, Qiu, Su, Yang, Chao-Yie, Yi, Han, Wang, Shaomeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997469/
https://ncbi.nlm.nih.gov/pubmed/20443226
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