Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites

BACKGROUND: Classical and quantitative linkage analyses of genetic crosses have traditionally been used to map genes of interest, such as those conferring chloroquine or quinine resistance in malaria parasites. Next-generation sequencing technologies now present the possibility of determining genome...

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Main Authors: Hunt, Paul, Martinelli, Axel, Modrzynska, Katarzyna, Borges, Sofia, Creasey, Alison, Rodrigues, Louise, Beraldi, Dario, Loewe, Laurence, Fawcett, Richard, Kumar, Sujai, Thomson, Marian, Trivedi, Urmi, Otto, Thomas D, Pain, Arnab, Blaxter, Mark, Cravo, Pedro
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2010
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996995/
https://ncbi.nlm.nih.gov/pubmed/20846421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-499
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