Genomewide Scan Reveals Amplification of mdr1 as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites

Multidrug-resistant Plasmodium falciparum malaria parasites pose a threat to effective drug control, even to artemisinin-based combination therapies (ACTs). Here we used linkage group selection and Solexa whole-genome resequencing to investigate the genetic basis of resistance to component drugs of...

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Bibliografiske detaljer
Main Authors: Borges, Sofia, Cravo, Pedro, Creasey, Alison, Fawcett, Richard, Modrzynska, Katarzyna, Rodrigues, Louise, Martinelli, Axel, Hunt, Paul
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186966/
https://ncbi.nlm.nih.gov/pubmed/21709099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01748-10
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