Experimental Evolution of Resistance to Artemisinin Combination Therapy Results in Amplification of the mdr1 Gene in a Rodent Malaria Parasite

BACKGROUND: Lacking suitable alternatives, the control of malaria increasingly depends upon Artemisinin Combination Treatments (ACT): resistance to these drugs would therefore be disastrous. For ACTs, the biology of resistance to the individual components has been investigated, but experimentally in...

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Главные авторы: Rodrigues, Louise A., Henriques, Gisela, Borges, Sofia T., Hunt, Paul, Sanchez, Cecília P., Martinelli, Axel, Cravo, Pedro
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904698/
https://ncbi.nlm.nih.gov/pubmed/20657645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011593
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