Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

BACKGROUND: The control of malaria, caused by Plasmodium falciparum, is hampered by the relentless evolution of drug resistance. Because artemisinin derivatives are now used in the most effective anti-malarial therapy, resistance to artemisinin would be catastrophic. Indeed, studies suggest that art...

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Autors principals: Henriques, Gisela, Martinelli, Axel, Rodrigues, Louise, Modrzynska, Katarzyna, Fawcett, Richard, Houston, Douglas R, Borges, Sofia T, d’Alessandro, Umberto, Tinto, Halidou, Karema, Corine, Hunt, Paul, Cravo, Pedro
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655824/
https://ncbi.nlm.nih.gov/pubmed/23561245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-12-118
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