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Whole genome re-sequencing identifies a mutation in an ABC transporter (mdr2) in a Plasmodium chabaudi clone with altered susceptibility to antifolate drugs()

In malaria parasites, mutations in two genes of folate biosynthesis encoding dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) modify responses to antifolate therapies which target these enzymes. However, the involvement of other genes which modify the availability of exogenous fola...

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Detalhes bibliográficos
Main Authors: Martinelli, Axel, Henriques, Gisela, Cravo, Pedro, Hunt, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034870/
https://ncbi.nlm.nih.gov/pubmed/20858498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpara.2010.08.008
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