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RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1

Editing of the pre-mRNA for the DNA repair enzyme NEIL1 causes a lysine to arginine change in the lesion recognition loop of the protein. The two forms of NEIL1 are shown here to have distinct enzymatic properties. The edited form removes thymine glycol from duplex DNA 30 times more slowly than the...

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Autors principals: Yeo, Jongchan, Goodman, Rena A., Schirle, Nicole T., David, Sheila S., Beal, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996456/
https://ncbi.nlm.nih.gov/pubmed/21068368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009231107
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