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RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1
Editing of the pre-mRNA for the DNA repair enzyme NEIL1 causes a lysine to arginine change in the lesion recognition loop of the protein. The two forms of NEIL1 are shown here to have distinct enzymatic properties. The edited form removes thymine glycol from duplex DNA 30 times more slowly than the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996456/ https://ncbi.nlm.nih.gov/pubmed/21068368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009231107 |
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