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Potent and Selective Inhibition of A-to-I RNA Editing with 2’-O-Methyl/Locked Nucleic Acid-containing Antisense Oligoribonucleotides
ADARs (adenosine deaminases acting on RNA) are RNA editing enzymes that bind double helical RNAs and deaminate select adenosines (A). The product inosine (I) is read during translation as guanosine (G) so such changes can alter codon meaning. ADAR-catalyzed A to I changes occur in coding sequences f...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3631459/ https://ncbi.nlm.nih.gov/pubmed/23394403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300692k |
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