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Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++
Computational efforts to identify functional elements within genomes leverage comparative sequence information by looking for regions that exhibit evidence of selective constraint. One way of detecting constrained elements is to follow a bottom-up approach by computing constraint scores for individu...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996323/ https://ncbi.nlm.nih.gov/pubmed/21152010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001025 |
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