Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomes

Here, we demonstrate how comparative sequence analysis facilitates genome-wide base-pair-level interpretation of individual genetic variation and address two questions of importance for human personal genomics: first, whether an individual's functional variation comes mostly from noncoding or c...

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Hlavní autoři: Goode, David L., Cooper, Gregory M., Schmutz, Jeremy, Dickson, Mark, Gonzales, Eidelyn, Tsai, Ming, Karra, Kalpana, Davydov, Eugene, Batzoglou, Serafim, Myers, Richard M., Sidow, Arend
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2010
Témata:
Letter
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840986/
https://ncbi.nlm.nih.gov/pubmed/20067941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.102210.109
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