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Distribution and intensity of constraint in mammalian genomic sequence

Comparisons of orthologous genomic DNA sequences can be used to characterize regions that have been subject to purifying selection and are enriched for functional elements. We here present the results of such an analysis on an alignment of sequences from 29 mammalian species. The alignment captures...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cooper, Gregory M., Stone, Eric A., Asimenos, George, Green, Eric D., Batzoglou, Serafim, Sidow, Arend
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1172034/
https://ncbi.nlm.nih.gov/pubmed/15965027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.3577405
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