Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++

Computational efforts to identify functional elements within genomes leverage comparative sequence information by looking for regions that exhibit evidence of selective constraint. One way of detecting constrained elements is to follow a bottom-up approach by computing constraint scores for individu...

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Main Authors: Davydov, Eugene V., Goode, David L., Sirota, Marina, Cooper, Gregory M., Sidow, Arend, Batzoglou, Serafim
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996323/
https://ncbi.nlm.nih.gov/pubmed/21152010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001025
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