AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture

Epidermal growth factor receptor (EGFR) overexpression and activation is critical in the initiation and progression of cancers, especially those of epithelial origin. EGFR activation is associated with the induction of divergent signal transduction pathways and a gamut of cellular processes; however...

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Detalhes bibliográficos
Main Authors: Oyama, K, Okawa, T, Nakagawa, H, Takaoka, M, Andl, CD, Kim, S-H, Klein-Szanto, A, Diehl, JA, Herlyn, M, El-Deiry, W, Rustgi, AK
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996093/
https://ncbi.nlm.nih.gov/pubmed/17043653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210025
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