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AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture

Epidermal growth factor receptor (EGFR) overexpression and activation is critical in the initiation and progression of cancers, especially those of epithelial origin. EGFR activation is associated with the induction of divergent signal transduction pathways and a gamut of cellular processes; however...

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Hlavní autoři: Oyama, K, Okawa, T, Nakagawa, H, Takaoka, M, Andl, CD, Kim, S-H, Klein-Szanto, A, Diehl, JA, Herlyn, M, El-Deiry, W, Rustgi, AK
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996093/
https://ncbi.nlm.nih.gov/pubmed/17043653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210025
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