The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

Esophageal cancer is a prototypic squamous cell cancer that carries a poor prognosis, primarily due to presentation at advanced stages. We used human esophageal epithelial cells as a platform to recapitulate esophageal squamous cell cancer, thereby providing insights into the molecular pathogenesis...

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Detalhes bibliográficos
Main Authors: Okawa, Takaomi, Michaylira, Carmen Z., Kalabis, Jiri, Stairs, Douglas B., Nakagawa, Hiroshi, Andl, Claudia, Johnstone, Cameron N., Klein-Szanto, Andres J., El-Deiry, Wafik S., Cukierman, Edna, Herlyn, Meenhard, Rustgi, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045132/
https://ncbi.nlm.nih.gov/pubmed/17974918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1544507
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