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BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib

Point mutations in the kinase domain of BCR-ABL are the most common mechanism of drug resistance in chronic myeloid leukemia (CML) patients treated with ABL kinase inhibitors, including imatinib. It has also been shown in vitro that mutations outside the kinase domain in the neighboring linker, SH2,...

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Main Authors: Sherbenou, Daniel W., Hantschel, Oliver, Kaupe, Ines, Willis, Stephanie, Bumm, Thomas, Turaga, Lalita P., Lange, Thoralf, Dao, Kim-Hien, Press, Richard D., Druker, Brian J., Superti-Furga, Giulio, Deininger, Michael W.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995357/
https://ncbi.nlm.nih.gov/pubmed/20519627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-183665
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