By-passing in vitro screening—next generation sequencing technologies applied to antibody display and in silico candidate selection

In recent years, unprecedented DNA sequencing capacity provided by next generation sequencing (NGS) has revolutionized genomic research. Combining the Illumina sequencing platform and a scFv library designed to confine diversity to both CDR3, >1.9 × 10(7) sequences have been generated. This appro...

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Bibliografiska uppgifter
Huvudupphovsmän: Ravn, U., Gueneau, F., Baerlocher, L., Osteras, M., Desmurs, M., Malinge, P., Magistrelli, G., Farinelli, L., Kosco-Vilbois, M.H., Fischer, N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Methods Online
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995085/
https://ncbi.nlm.nih.gov/pubmed/20846958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq789
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