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By-passing in vitro screening—next generation sequencing technologies applied to antibody display and in silico candidate selection
In recent years, unprecedented DNA sequencing capacity provided by next generation sequencing (NGS) has revolutionized genomic research. Combining the Illumina sequencing platform and a scFv library designed to confine diversity to both CDR3, >1.9 × 10(7) sequences have been generated. This appro...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Oxford University Press
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995085/ https://ncbi.nlm.nih.gov/pubmed/20846958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq789 |
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