HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements

7SK snRNA, an abundant RNA discovered in human nucleus, regulates transcription by RNA polymerase II (RNAPII). It sequesters and inhibits the transcription elongation factor P-TEFb which, by phosphorylation of RNAPII, switches transcription from initiation to processive elongation and relieves pause...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lebars, Isabelle, Martinez-Zapien, D., Durand, A., Coutant, J., Kieffer, B., Dock-Bregeon, Anne-Catherine
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2010
Pynciau:
RNA
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995076/
https://ncbi.nlm.nih.gov/pubmed/20675720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq660
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