HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements

7SK snRNA, an abundant RNA discovered in human nucleus, regulates transcription by RNA polymerase II (RNAPII). It sequesters and inhibits the transcription elongation factor P-TEFb which, by phosphorylation of RNAPII, switches transcription from initiation to processive elongation and relieves pause...

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Autores principales: Lebars, Isabelle, Martinez-Zapien, D., Durand, A., Coutant, J., Kieffer, B., Dock-Bregeon, Anne-Catherine
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
Materias:
RNA
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995076/
https://ncbi.nlm.nih.gov/pubmed/20675720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq660
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