Beta-Cell Selective K(ATP)-Channel Activation Protects Beta-Cells and Human Islets from Human Islet Amyloid Polypeptide Induced Toxicity

BACKGROUND AND AIMS: In type 2 diabetes mellitus (T2DM) chronic beta-cell stimulation and oligomers of aggregating human islet amyloid polypeptide (h-IAPP) cause beta-cell dysfunction and induce beta-cell apoptosis. Therefore we asked whether beta-cell rest prevents h-IAPP induced beta-cell apoptosi...

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Hauptverfasser: Ritzel, Robert A., Jayasinghe, Sajith, Hansen, John B., Sturis, Jeppe, Langen, Ralf, Butler, Peter C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995001/
https://ncbi.nlm.nih.gov/pubmed/20619299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.regpep.2010.06.009
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