Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

Chronic ethanol consumption in the Long-Evans (LE) rat has been associated with hepatic p53 activation, and inhibition of the insulin/PI3K/AKT signal transduction cascade due to increased expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN). We hypothesize that p53 activati...

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Autori principali: Derdak, Zoltan, Lang, Charles H., Villegas, Kristine A., Tong, Ming, Mark, Nicholas M., de la Monte, Suzanne M., Wands, Jack R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994971/
https://ncbi.nlm.nih.gov/pubmed/20961644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2010.08.007
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