Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

BACKGROUND & AIMS: p53 and its transcriptional target miRNA34a have been implicated in the pathogenesis of fatty liver. We tested the efficacy of a p53 inhibitor, pifithrin-α p-nitro (PFT) in attenuating steatosis, associated oxidative stress and apoptosis in a murine model of non-alcoholic fatt...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Derdak, Zoltan, Villegas, Kristine A., Harb, Ragheb, Wu, Annie M., Sousa, Aryanna, Wands, Jack R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612370/
https://ncbi.nlm.nih.gov/pubmed/23211317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2012.11.042
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk