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Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease
Chronic ethanol consumption in the Long-Evans (LE) rat has been associated with hepatic p53 activation, and inhibition of the insulin/PI3K/AKT signal transduction cascade due to increased expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN). We hypothesize that p53 activati...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2994971/ https://ncbi.nlm.nih.gov/pubmed/20961644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2010.08.007 |
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