Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2

Cholera toxin (CT) causes the massive secretory diarrhea associated with epidemic cholera. To induce disease, CT enters the cytosol of host cells by co-opting a lipid-based sorting pathway from the plasma membrane, through the trans-Golgi network (TGN), and into the endoplasmic reticulum (ER). In th...

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Autors principals: Saslowsky, David E., Cho, Jin Ah, Chinnapen, Himani, Massol, Ramiro H., Chinnapen, Daniel J.-F., Wagner, Jessica S., De Luca, Heidi E., Kam, Wendy, Paw, Barry H., Lencer, Wayne I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994338/
https://ncbi.nlm.nih.gov/pubmed/21041954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42958
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