Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase

BACKGROUND: Potentiation of anticancer activity of capecitabine is required to improve its therapeutic index. In colorectal cancer (CRC) cells, we evaluated whether the histone deacetylase-inhibitor vorinostat may induce synergistic antitumour effects in combination with capecitabine by modulating t...

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Bibliografiske detaljer
Main Authors: Di Gennaro, E, Piro, G, Chianese, M I, Franco, R, Cintio, A Di, Moccia, T, Luciano, A, de Ruggiero, I, Bruzzese, F, Avallone, A, Arra, C, Budillon, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994231/
https://ncbi.nlm.nih.gov/pubmed/21045833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605969
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