A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration

To define the functional pathways regulating epithelial cell migration, we performed a genome-wide RNAi screen using 55,000 pooled lentiviral shRNAs targeting ∼11,000 genes, selecting for transduced cells with increased motility. A stringent validation protocol generated a set of 31 genes representi...

詳細記述

保存先:
書誌詳細
主要な著者: Smolen, Gromoslaw A., Zhang, Jianmin, Zubrowski, Matthew J., Edelman, Elena J., Luo, Biao, Yu, Min, Ng, Lydia W., Scherber, Cally M., Schott, Benjamin J., Ramaswamy, Sridhar, Irimia, Daniel, Root, David E., Haber, Daniel A.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2010
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994039/
https://ncbi.nlm.nih.gov/pubmed/21062900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1989110
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