A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration

To define the functional pathways regulating epithelial cell migration, we performed a genome-wide RNAi screen using 55,000 pooled lentiviral shRNAs targeting ∼11,000 genes, selecting for transduced cells with increased motility. A stringent validation protocol generated a set of 31 genes representi...

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Detalhes bibliográficos
Main Authors: Smolen, Gromoslaw A., Zhang, Jianmin, Zubrowski, Matthew J., Edelman, Elena J., Luo, Biao, Yu, Min, Ng, Lydia W., Scherber, Cally M., Schott, Benjamin J., Ramaswamy, Sridhar, Irimia, Daniel, Root, David E., Haber, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994039/
https://ncbi.nlm.nih.gov/pubmed/21062900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1989110
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