BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy

B cell lymphoma 6 (BCL6), which encodes a transcriptional repressor, is a critical oncogene in diffuse large B cell lymphomas (DLBCLs). Although a retro-inverted BCL6 peptide inhibitor (RI-BPI) was recently shown to potently kill DLBCL cells, the underlying mechanisms remain unclear. Here, we show t...

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Main Authors: Cerchietti, Leandro C., Hatzi, Katerina, Caldas-Lopes, Eloisi, Yang, Shao Ning, Figueroa, Maria E., Morin, Ryan D., Hirst, Martin, Mendez, Lourdes, Shaknovich, Rita, Cole, Philip A., Bhalla, Kapil, Gascoyne, Randy D., Marra, Marco, Chiosis, Gabriela, Melnick, Ari
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993589/
https://ncbi.nlm.nih.gov/pubmed/21041953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42869
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