Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

Increased sarcoplasmic reticulum (SR) Ca(2+) leak via the cardiac ryanodine receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) progression. Inhibition of this leak is an emerging therapeutic strategy. To explore the role of chronic PKA phosphorylation of RyR2 in...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Shan, Jian, Betzenhauser, Matthew J., Kushnir, Alexander, Reiken, Steven, Meli, Albano C., Wronska, Anetta, Dura, Miroslav, Chen, Bi-Xing, Marks, Andrew R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993577/
https://ncbi.nlm.nih.gov/pubmed/21099115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37649
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky