Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

Increased sarcoplasmic reticulum (SR) Ca(2+) leak via the cardiac ryanodine receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) progression. Inhibition of this leak is an emerging therapeutic strategy. To explore the role of chronic PKA phosphorylation of RyR2 in...

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Detalhes bibliográficos
Main Authors: Shan, Jian, Betzenhauser, Matthew J., Kushnir, Alexander, Reiken, Steven, Meli, Albano C., Wronska, Anetta, Dura, Miroslav, Chen, Bi-Xing, Marks, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993577/
https://ncbi.nlm.nih.gov/pubmed/21099115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37649
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