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Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

Increased sarcoplasmic reticulum (SR) Ca(2+) leak via the cardiac ryanodine receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) progression. Inhibition of this leak is an emerging therapeutic strategy. To explore the role of chronic PKA phosphorylation of RyR2 in...

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書誌詳細
主要な著者: Shan, Jian, Betzenhauser, Matthew J., Kushnir, Alexander, Reiken, Steven, Meli, Albano C., Wronska, Anetta, Dura, Miroslav, Chen, Bi-Xing, Marks, Andrew R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993577/
https://ncbi.nlm.nih.gov/pubmed/21099115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37649
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